Interest statement

The author(s) declare that they have no conflict of interest.

References

[1] Alagoz Y., Gurkok T., Zhang B., Unver T.. Manipulating the biosynthesis of bioactive compound alkaloids for next-generation metabolic engineering in opium poppy using CRISPR-Cas 9 genome editing technology. Sci Rep, 2016, 6: 30910 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Manipulating the biosynthesis of bioactive compound alkaloids for next-generation metabolic engineering in opium poppy using CRISPR-Cas 9 genome editing technology&author=Alagoz Y.&author=Gurkok T.&author=Zhang B.&author=Unver T.&publication_year=2016&journal=Sci Rep&volume=6&pages=30910

[2] Ainley W.M., Sastry-Dent L., Welter M.E., Murray M.G., Zeitler B., Amora R., Corbin D.R., Miles R.R., Arnold N.L., Strange T.L., Simpson M.A., Cao Z., Carroll C., Pawelczak K.S., Blue R., West K., Rowland L.M., Perkins D., Samuel P., Dewes C.M., Shen L., Sriram S., Evans S.L., Rebar E.J., Zhang L., Gregory P.D., Urnov F.D., Webb S.R., Petolino J.F.. Trait stacking via targeted genome editing. Plant Biotechnol J, 2013, 11: 1126-1134 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Trait stacking via targeted genome editing&author=Ainley W.M.&author=Sastry-Dent L.&author=Welter M.E.&author=Murray M.G.&author=Zeitler B.&author=Amora R.&author=Corbin D.R.&author=Miles R.R.&author=Arnold N.L.&author=Strange T.L.&author=Simpson M.A.&author=Cao Z.&author=Carroll C.&author=Pawelczak K.S.&author=Blue R.&author=West K.&author=Rowland L.M.&author=Perkins D.&author=Samuel P.&author=Dewes C.M.&author=Shen L.&author=Sriram S.&author=Evans S.L.&author=Rebar E.J.&author=Zhang L.&author=Gregory P.D.&author=Urnov F.D.&author=Webb S.R.&author=Petolino J.F.&publication_year=2013&journal=Plant Biotechnol J&volume=11&pages=1126-1134

[3] Ali Z., Abul-faraj A., Li L., Ghosh N., Piatek M., Mahjoub A., Aouida M., Piatek A., Baltes N.J., Voytas D.F., Dinesh-Kumar S., Mahfouz M.M.. Efficient virus-mediated genome editing in plants using the CRISPR/Cas9 system. Mol Plant, 2015, 8: 1288-1291 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient virus-mediated genome editing in plants using the CRISPR/Cas9 system&author=Ali Z.&author=Abul-faraj A.&author=Li L.&author=Ghosh N.&author=Piatek M.&author=Mahjoub A.&author=Aouida M.&author=Piatek A.&author=Baltes N.J.&author=Voytas D.F.&author=Dinesh-Kumar S.&author=Mahfouz M.M.&publication_year=2015&journal=Mol Plant&volume=8&pages=1288-1291

[4] Altpeter F., Springer N.M., Bartley L.E., Blechl A.E., Brutnell T.P., Citovsky V., Conrad L.J., Gelvin S.B., Jackson D.P., Kausch A.P., Lemaux P.G., Medford J.I., Orozco-Cárdenas M.L., Tricoli D.M., Van Eck J., Voytas D.F., Walbot V., Wang K., Zhang Z.J., Stewart C.N.. Advancing crop transformation in the era of genome editing. Plant Cell, 2016, 28: 1510-1520 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Advancing crop transformation in the era of genome editing&author=Altpeter F.&author=Springer N.M.&author=Bartley L.E.&author=Blechl A.E.&author=Brutnell T.P.&author=Citovsky V.&author=Conrad L.J.&author=Gelvin S.B.&author=Jackson D.P.&author=Kausch A.P.&author=Lemaux P.G.&author=Medford J.I.&author=Orozco-Cárdenas M.L.&author=Tricoli D.M.&author=Van Eck J.&author=Voytas D.F.&author=Walbot V.&author=Wang K.&author=Zhang Z.J.&author=Stewart C.N.&publication_year=2016&journal=Plant Cell&volume=28&pages=1510-1520

[5] Andersson M., Turesson H., Nicolia A., F?lt A.S., Samuelsson M., Hofvander P.. Efficient targeted multiallelic mutagenesis in tetraploid potato (Solanum tuberosum) by transient CRISPR-Cas9 expression in protoplasts. Plant Cell Rep, 2017, 36: 117-128 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient targeted multiallelic mutagenesis in tetraploid potato (Solanum tuberosum) by transient CRISPR-Cas9 expression in protoplasts&author=Andersson M.&author=Turesson H.&author=Nicolia A.&author=F?lt A.S.&author=Samuelsson M.&author=Hofvander P.&publication_year=2017&journal=Plant Cell Rep&volume=36&pages=117-128

[6] Baltes N.J., Gil-Humanes J., Cermak T., Atkins P.A., Voytas D.F.. DNA replicons for plant genome engineering. Plant Cell, 2014, 26: 151-163 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=DNA replicons for plant genome engineering&author=Baltes N.J.&author=Gil-Humanes J.&author=Cermak T.&author=Atkins P.A.&author=Voytas D.F.&publication_year=2014&journal=Plant Cell&volume=26&pages=151-163

[7] Belhaj K., Chaparro-Garcia A., Kamoun S., Nekrasov V.. Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system. Plant Methods, 2013, 9: 39 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system&author=Belhaj K.&author=Chaparro-Garcia A.&author=Kamoun S.&author=Nekrasov V.&publication_year=2013&journal=Plant Methods&volume=9&pages=39

[8] Beetham P.R., Kipp P.B., Sawycky X.L., Arntzen C.J., May G.D.. A tool for functional plant genomics: chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations. Proc Natl Acad Sci USA, 1999, 96: 8774-8778 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=A tool for functional plant genomics: chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations&author=Beetham P.R.&author=Kipp P.B.&author=Sawycky X.L.&author=Arntzen C.J.&author=May G.D.&publication_year=1999&journal=Proc Natl Acad Sci USA&volume=96&pages=8774-8778

[9] Bortesi L., Fischer R.. The CRISPR/Cas9 system for plant genome editing and beyond. Biotech Adv, 2015, 33: 41-52 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=The CRISPR/Cas9 system for plant genome editing and beyond&author=Bortesi L.&author=Fischer R.&publication_year=2015&journal=Biotech Adv&volume=33&pages=41-52

[10] Brooks C., Nekrasov V., Lippman Z.B., Van Eck J.. Efficient gene editing in tomato in the first generation using the clustered regularly interspaced short palindromic repeats/CRISPR-associated9 system. Plant Physiol, 2014, 166: 1292-1297 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient gene editing in tomato in the first generation using the clustered regularly interspaced short palindromic repeats/CRISPR-associated9 system&author=Brooks C.&author=Nekrasov V.&author=Lippman Z.B.&author=Van Eck J.&publication_year=2014&journal=Plant Physiol&volume=166&pages=1292-1297

[11] Butler N.M., Atkins P.A., Voytas D.F., Douches D.S.. Generation and inheritance of targeted mutations in potato (Solanum tuberosum L.) using the CRISPR/Cas system. PLoS ONE, 2015, 10: e0144591 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Generation and inheritance of targeted mutations in potato (Solanum tuberosum L.) using the CRISPR/Cas system&author=Butler N.M.&author=Atkins P.A.&author=Voytas D.F.&author=Douches D.S.&publication_year=2015&journal=PLoS ONE&volume=10&pages=e0144591

[12] Cai Y., Chen L., Liu X., Sun S., Wu C., Jiang B., Han T., Hou W.. CRISPR/Cas9-mediated genome editing in soybean hairy roots. PLoS ONE, 2015, 10: e0136064 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=CRISPR/Cas9-mediated genome editing in soybean hairy roots&author=Cai Y.&author=Chen L.&author=Liu X.&author=Sun S.&author=Wu C.&author=Jiang B.&author=Han T.&author=Hou W.&publication_year=2015&journal=PLoS ONE&volume=10&pages=e0136064

[13] Cai C.Q., Doyon Y., Ainley W.M., Miller J.C., Dekelver R.C., Moehle E.A., Rock J.M., Lee Y.L., Garrison R., Schulenberg L., Blue R., Worden A., Baker L., Faraji F., Zhang L., Holmes M.C., Rebar E.J., Collingwood T.N., Rubin-Wilson B., Gregory P.D., Urnov F.D., Petolino J.F.. Targeted transgene integration in plant cells using designed zinc finger nucleases. Plant Mol Biol, 2009, 69: 699-709 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted transgene integration in plant cells using designed zinc finger nucleases&author=Cai C.Q.&author=Doyon Y.&author=Ainley W.M.&author=Miller J.C.&author=Dekelver R.C.&author=Moehle E.A.&author=Rock J.M.&author=Lee Y.L.&author=Garrison R.&author=Schulenberg L.&author=Blue R.&author=Worden A.&author=Baker L.&author=Faraji F.&author=Zhang L.&author=Holmes M.C.&author=Rebar E.J.&author=Collingwood T.N.&author=Rubin-Wilson B.&author=Gregory P.D.&author=Urnov F.D.&author=Petolino J.F.&publication_year=2009&journal=Plant Mol Biol&volume=69&pages=699-709

[14] Cao M.X., Huang J.Q., Yao Q.H., Liu S.J., Wang C.L., Wei Z.M.. Site-specific DNA excision in transgenic rice with a cell-permeable cre recombinase. Mol Biotechnol, 2006, 32: 055-064 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Site-specific DNA excision in transgenic rice with a cell-permeable cre recombinase&author=Cao M.X.&author=Huang J.Q.&author=Yao Q.H.&author=Liu S.J.&author=Wang C.L.&author=Wei Z.M.&publication_year=2006&journal=Mol Biotechnol&volume=32&pages=055-064

[15] ?ermák T., Baltes N.J., ?egan R., Zhang Y., Voytas D.F.. High-frequency, precise modification of the tomato genome. Genome Biol, 2015, 16: 232 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=High-frequency, precise modification of the tomato genome&author=?ermák T.&author=Baltes N.J.&author=?egan R.&author=Zhang Y.&author=Voytas D.F.&publication_year=2015&journal=Genome Biol&volume=16&pages=232

[16] Chandrasekaran J., Brumin M., Wolf D., Leibman D., Klap C., Pearlsman M., Sherman A., Arazi T., Gal-On A.. Development of broad virus resistance in non-transgenic cucumber using CRISPR/Cas9 technology. Mol Plant Pathol, 2016, 17: 1140-1153 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Development of broad virus resistance in non-transgenic cucumber using CRISPR/Cas9 technology&author=Chandrasekaran J.&author=Brumin M.&author=Wolf D.&author=Leibman D.&author=Klap C.&author=Pearlsman M.&author=Sherman A.&author=Arazi T.&author=Gal-On A.&publication_year=2016&journal=Mol Plant Pathol&volume=17&pages=1140-1153

[17] Char S.N., Unger-Wallace E., Frame B., Briggs S.A., Main M., Spalding M.H., Vollbrecht E., Wang K., Yang B.. Heritable site-specific mutagenesis using TALENs in maize. Plant Biotechnol J, 2015, 13: 1002-1010 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Heritable site-specific mutagenesis using TALENs in maize&author=Char S.N.&author=Unger-Wallace E.&author=Frame B.&author=Briggs S.A.&author=Main M.&author=Spalding M.H.&author=Vollbrecht E.&author=Wang K.&author=Yang B.&publication_year=2015&journal=Plant Biotechnol J&volume=13&pages=1002-1010

[18] Chugh A., Eudes F., Shim Y.S.. Cell-penetrating peptides: nanocarrier for macromolecule delivery in living cells. IUBMB Life, 2010, 62: 183-193 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Cell-penetrating peptides: nanocarrier for macromolecule delivery in living cells&author=Chugh A.&author=Eudes F.&author=Shim Y.S.&publication_year=2010&journal=IUBMB Life&volume=62&pages=183-193

[19] Clasen B.M., Stoddard T.J., Luo S., Demorest Z.L., Li J., Cedrone F., Tibebu R., Davison S., Ray E.E., Daulhac A., Coffman A., Yabandith A., Retterath A., Haun W., Baltes N.J., Mathis L., Voytas D.F., Zhang F.. Improving cold storage and processing traits in potato through targeted gene knockout. Plant Biotechnol J, 2016, 14: 169-176 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Improving cold storage and processing traits in potato through targeted gene knockout&author=Clasen B.M.&author=Stoddard T.J.&author=Luo S.&author=Demorest Z.L.&author=Li J.&author=Cedrone F.&author=Tibebu R.&author=Davison S.&author=Ray E.E.&author=Daulhac A.&author=Coffman A.&author=Yabandith A.&author=Retterath A.&author=Haun W.&author=Baltes N.J.&author=Mathis L.&author=Voytas D.F.&author=Zhang F.&publication_year=2016&journal=Plant Biotechnol J&volume=14&pages=169-176

[20] Cole-Strauss A., Yoon K., Xiang Y., Byrne B.C., Rice M.C., Gryn J., Holloman W.K., Kmiec E.B.. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science, 1996, 273: 1386-1389 CrossRef ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide&author=Cole-Strauss A.&author=Yoon K.&author=Xiang Y.&author=Byrne B.C.&author=Rice M.C.&author=Gryn J.&author=Holloman W.K.&author=Kmiec E.B.&publication_year=1996&journal=Science&volume=273&pages=1386-1389

[21] Curtin S.J., Zhang F., Sander J.D., Haun W.J., Starker C., Baltes N.J., Reyon D., Dahlborg E.J., Goodwin M.J., Coffman A.P., Dobbs D., Joung J.K., Voytas D.F., Stupar R.M.. Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases. Plant Physiol, 2011, 156: 466-473 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases&author=Curtin S.J.&author=Zhang F.&author=Sander J.D.&author=Haun W.J.&author=Starker C.&author=Baltes N.J.&author=Reyon D.&author=Dahlborg E.J.&author=Goodwin M.J.&author=Coffman A.P.&author=Dobbs D.&author=Joung J.K.&author=Voytas D.F.&author=Stupar R.M.&publication_year=2011&journal=Plant Physiol&volume=156&pages=466-473

[22] de Pater S., Neuteboom L.W., Pinas J.E., Hooykaas P.J.J., van der Zaal B.J.. ZFN-induced mutagenesis and gene-targeting in Arabidopsis through Agrobacterium-mediated floral dip transformation. Plant Biotech J, 2009, 7: 821-835 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=ZFN-induced mutagenesis and gene-targeting in Arabidopsis through Agrobacterium-mediated floral dip transformation&author=de Pater S.&author=Neuteboom L.W.&author=Pinas J.E.&author=Hooykaas P.J.J.&author=van der Zaal B.J.&publication_year=2009&journal=Plant Biotech J&volume=7&pages=821-835

[23] de Pater S., Pinas J.E., Hooykaas P.J.J., van der Zaal B.J.. ZFN-mediated gene targeting of the Arabidopsis protoporphyrinogen oxidase gene through Agrobacterium-mediated floral dip transformation. Plant Biotechnol J, 2013, 11: 510-515 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=ZFN-mediated gene targeting of the Arabidopsis protoporphyrinogen oxidase gene through Agrobacterium-mediated floral dip transformation&author=de Pater S.&author=Pinas J.E.&author=Hooykaas P.J.J.&author=van der Zaal B.J.&publication_year=2013&journal=Plant Biotechnol J&volume=11&pages=510-515

[24] Dinesh-Kumar, S.P., Anandalakshmi, R., Marathe, R., Schiff, M., and Liu, Y. (2003). Virus-induced gene silencing. Methods Mol Biol 236, 287–294. Google Scholar http://scholar.google.com/scholar_lookup?title=Dinesh-Kumar, S.P., Anandalakshmi, R., Marathe, R., Schiff, M., and Liu, Y. (2003). Virus-induced gene silencing. Methods Mol Biol 236, 287–294&

[25] Dong C., Beetham P., Vincent K., Sharp P.. Oligonucleotide-directed gene repair in wheat using a transient plasmid gene repair assay system. Plant Cell Rep, 2006, 25: 457-465 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Oligonucleotide-directed gene repair in wheat using a transient plasmid gene repair assay system&author=Dong C.&author=Beetham P.&author=Vincent K.&author=Sharp P.&publication_year=2006&journal=Plant Cell Rep&volume=25&pages=457-465

[26] Du J., Jin J., Yan M., Lu Y.. Synthetic nanocarriers for intracellular protein delivery. Curr Drug Metab, 2012, 13: 82-92 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Synthetic nanocarriers for intracellular protein delivery&author=Du J.&author=Jin J.&author=Yan M.&author=Lu Y.&publication_year=2012&journal=Curr Drug Metab&volume=13&pages=82-92

[27] Du H., Zeng X., Zhao M., Cui X., Wang Q., Yang H., Cheng H., Yu D.. Efficient targeted mutagenesis in soybean by TALENs and CRISPR/Cas9. J Biotech, 2016, 217: 90-97 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient targeted mutagenesis in soybean by TALENs and CRISPR/Cas9&author=Du H.&author=Zeng X.&author=Zhao M.&author=Cui X.&author=Wang Q.&author=Yang H.&author=Cheng H.&author=Yu D.&publication_year=2016&journal=J Biotech&volume=217&pages=90-97

[28] English J., Davenport G., Elmayan T., Vaucheret H., Baulcombe D.. Requirement of sense transcription for homology-dependent virus resistance and trans-inactivation. Plant J, 1997, 12: 597-603 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Requirement of sense transcription for homology-dependent virus resistance and trans-inactivation&author=English J.&author=Davenport G.&author=Elmayan T.&author=Vaucheret H.&author=Baulcombe D.&publication_year=1997&journal=Plant J&volume=12&pages=597-603

[29] Fan D., Liu T., Li C., Jiao B., Li S., Hou Y., Luo K.. Efficient CRISPR/Cas9-mediated targeted mutagenesis in Populus in the first generation. Sci Rep, 2015, 5: 12217 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient CRISPR/Cas9-mediated targeted mutagenesis in Populus in the first generation&author=Fan D.&author=Liu T.&author=Li C.&author=Jiao B.&author=Li S.&author=Hou Y.&author=Luo K.&publication_year=2015&journal=Sci Rep&volume=5&pages=12217

[30] Fauser F., Schiml S., Puchta H.. Both CRISPR/Cas-based nucleases and nickases can be used efficiently for genome engineering in Arabidopsis thaliana. Plant J, 2014, 79: 348-359 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Both CRISPR/Cas-based nucleases and nickases can be used efficiently for genome engineering in Arabidopsis thaliana&author=Fauser F.&author=Schiml S.&author=Puchta H.&publication_year=2014&journal=Plant J&volume=79&pages=348-359

[31] Feng Z., Zhang B., Ding W., Liu X., Yang D.L., Wei P., Cao F., Zhu S., Zhang F., Mao Y., Zhu J.K.. Efficient genome editing in plants using a CRISPR/Cas system. Cell Res, 2013, 23: 1229-1232 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient genome editing in plants using a CRISPR/Cas system&author=Feng Z.&author=Zhang B.&author=Ding W.&author=Liu X.&author=Yang D.L.&author=Wei P.&author=Cao F.&author=Zhu S.&author=Zhang F.&author=Mao Y.&author=Zhu J.K.&publication_year=2013&journal=Cell Res&volume=23&pages=1229-1232

[32] Feng Z., Mao Y., Xu N., Zhang B., Wei P., Yang D.L., Wang Z., Zhang Z., Zheng R., Yang L., Zeng L., Liu X., Zhu J.K.. Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis. Proc Natl Acad Sci USA, 2014, 111: 4632-4637 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis&author=Feng Z.&author=Mao Y.&author=Xu N.&author=Zhang B.&author=Wei P.&author=Yang D.L.&author=Wang Z.&author=Zhang Z.&author=Zheng R.&author=Yang L.&author=Zeng L.&author=Liu X.&author=Zhu J.K.&publication_year=2014&journal=Proc Natl Acad Sci USA&volume=111&pages=4632-4637

[33] Forner J., Pfeiffer A., Langenecker T., Manavella P.A., Manavella P., Lohmann J.U.. Germline-transmitted genome editing in Arabidopsis thaliana using TAL-effector-nucleases. PLoS ONE, 2015, 10: e0121056 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Germline-transmitted genome editing in Arabidopsis thaliana using TAL-effector-nucleases&author=Forner J.&author=Pfeiffer A.&author=Langenecker T.&author=Manavella P.A.&author=Manavella P.&author=Lohmann J.U.&publication_year=2015&journal=PLoS ONE&volume=10&pages=e0121056

[34] Forsyth A., Weeks T., Richael C., Duan H.. Transcription activator-like effector nucleases (TALEN)-mediated targeted DNA insertion in potato plants. Front Plant Sci, 2016, 7: 1572 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Transcription activator-like effector nucleases (TALEN)-mediated targeted DNA insertion in potato plants&author=Forsyth A.&author=Weeks T.&author=Richael C.&author=Duan H.&publication_year=2016&journal=Front Plant Sci&volume=7&pages=1572

[35] Gao J., Wang G., Ma S., Xie X., Wu X., Zhang X., Wu Y., Zhao P., Xia Q.. CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum. Plant Mol Biol, 2015, 87: 99-110 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum&author=Gao J.&author=Wang G.&author=Ma S.&author=Xie X.&author=Wu X.&author=Zhang X.&author=Wu Y.&author=Zhao P.&author=Xia Q.&publication_year=2015&journal=Plant Mol Biol&volume=87&pages=99-110

[36] Gelvin S.B.. Agrobacterium-mediated plant transformation: the biology behind the “Gene-Jockeying” tool. Microbiol Mol Biol Rev, 2003, 67: 16-37 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Agrobacterium-mediated plant transformation: the biology behind the “Gene-Jockeying” tool&author=Gelvin S.B.&publication_year=2003&journal=Microbiol Mol Biol Rev&volume=67&pages=16-37

[37] Gil-Humanes J., Wang Y., Liang Z., Shan Q., Ozuna C.V., Sánchez-León S., Baltes N.J., Starker C., Barro F., Gao C., Voytas D.F.. High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9. Plant J, 2017, 89: 1251-1262 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9&author=Gil-Humanes J.&author=Wang Y.&author=Liang Z.&author=Shan Q.&author=Ozuna C.V.&author=Sánchez-León S.&author=Baltes N.J.&author=Starker C.&author=Barro F.&author=Gao C.&author=Voytas D.F.&publication_year=2017&journal=Plant J&volume=89&pages=1251-1262

[38] Gupta M., DeKelver R.C., Palta A., Clifford C., Gopalan S., Miller J.C., Novak S., Desloover D., Gachotte D., Connell J., Flook J., Patterson T., Robbins K., Rebar E.J., Gregory P.D., Urnov F.D., Petolino J.F.. Transcriptional activation of Brassica napus β-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor. Plant Biotech J, 2012, 10: 783-791 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Transcriptional activation of Brassica napus β-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor&author=Gupta M.&author=DeKelver R.C.&author=Palta A.&author=Clifford C.&author=Gopalan S.&author=Miller J.C.&author=Novak S.&author=Desloover D.&author=Gachotte D.&author=Connell J.&author=Flook J.&author=Patterson T.&author=Robbins K.&author=Rebar E.J.&author=Gregory P.D.&author=Urnov F.D.&author=Petolino J.F.&publication_year=2012&journal=Plant Biotech J&volume=10&pages=783-791

[39] Gurushidze M., Hensel G., Hiekel S., Schedel S., Valkov V., Kumlehn J.. True-breeding targeted gene knock-out in barley using designer TALE-nuclease in haploid cells. PLoS ONE, 2014, 9: e92046 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=True-breeding targeted gene knock-out in barley using designer TALE-nuclease in haploid cells&author=Gurushidze M.&author=Hensel G.&author=Hiekel S.&author=Schedel S.&author=Valkov V.&author=Kumlehn J.&publication_year=2014&journal=PLoS ONE&volume=9&pages=e92046

[40] Hartung F., Schiemann J.. Precise plant breeding using new genome editing techniques: opportunities, safety and regulation in the EU. Plant J, 2014, 78: 742-752 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Precise plant breeding using new genome editing techniques: opportunities, safety and regulation in the EU&author=Hartung F.&author=Schiemann J.&publication_year=2014&journal=Plant J&volume=78&pages=742-752

[41] Haun W., Coffman A., Clasen B.M., Demorest Z.L., Lowy A., Ray E., Retterath A., Stoddard T., Juillerat A., Cedrone F., Mathis L., Voytas D.F., Zhang F.. Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family. Plant Biotechnol J, 2014, 12: 934-940 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family&author=Haun W.&author=Coffman A.&author=Clasen B.M.&author=Demorest Z.L.&author=Lowy A.&author=Ray E.&author=Retterath A.&author=Stoddard T.&author=Juillerat A.&author=Cedrone F.&author=Mathis L.&author=Voytas D.F.&author=Zhang F.&publication_year=2014&journal=Plant Biotechnol J&volume=12&pages=934-940

[42] Huang Y.W., Lee H.J., Tolliver L.M., Aronstam R.S.. Delivery of nucleic acids and nanomaterials by cell-penetrating peptides: opportunities and challenges. BioMed Res Int, 2015, 2015: 1-16 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Delivery of nucleic acids and nanomaterials by cell-penetrating peptides: opportunities and challenges&author=Huang Y.W.&author=Lee H.J.&author=Tolliver L.M.&author=Aronstam R.S.&publication_year=2015&journal=BioMed Res Int&volume=2015&pages=1-16

[43] Ito Y., Nishizawa-Yokoi A., Endo M., Mikami M., Toki S.. CRISPR/Cas9-mediated mutagenesis of the RIN locus that regulates tomato fruit ripening. Biochem Biophys Res Commun, 2015, 467: 76-82 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=CRISPR/Cas9-mediated mutagenesis of the RIN locus that regulates tomato fruit ripening&author=Ito Y.&author=Nishizawa-Yokoi A.&author=Endo M.&author=Mikami M.&author=Toki S.&publication_year=2015&journal=Biochem Biophys Res Commun&volume=467&pages=76-82

[44] Jacobs T.B., LaFayette P.R., Schmitz R.J., Parrott W.A.. Targeted genome modifications in soybean with CRISPR/Cas9. BMC Biotechnol, 2015, 15: 16 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted genome modifications in soybean with CRISPR/Cas9&author=Jacobs T.B.&author=LaFayette P.R.&author=Schmitz R.J.&author=Parrott W.A.&publication_year=2015&journal=BMC Biotechnol&volume=15&pages=16

[45] Jensen, S.P., Febres, V.J., and Moore, G.A. (2014). Cell penetrating peptides as an alternative transformation method in citrus. J Citrus Pathol 1, 10.15. Google Scholar http://scholar.google.com/scholar_lookup?title=Jensen, S.P., Febres, V.J., and Moore, G.A. (2014). Cell penetrating peptides as an alternative transformation method in citrus. J Citrus Pathol 1, 10.15&

[46] Jia H., Wang N.. Targeted genome editing of sweet orange using Cas9/sgRNA. PLoS ONE, 2014a, 9: e93806 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted genome editing of sweet orange using Cas9/sgRNA&author=Jia H.&author=Wang N.&publication_year=2014a&journal=PLoS ONE&volume=9&pages=e93806

[47] Jia H., Wang N.. Xcc-facilitated agroinfiltration of citrus leaves: a tool for rapid functional analysis of transgenes in citrus leaves. Plant Cell Rep, 2014b, 33: 1993-2001 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Xcc-facilitated agroinfiltration of citrus leaves: a tool for rapid functional analysis of transgenes in citrus leaves&author=Jia H.&author=Wang N.&publication_year=2014b&journal=Plant Cell Rep&volume=33&pages=1993-2001

[48] Jia H., Orbovic V., Jones J.B., Wang N.. Modification of the PthA4 effector binding elements in Type I CsLOB1 promoter using Cas9/sgRNA to produce transgenic Duncan grapefruit alleviating XccΔpthA4:dCsLOB1.3 infection. Plant Biotechnol J, 2016, 14: 1291-1301 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Modification of the PthA4 effector binding elements in Type I CsLOB1 promoter using Cas9/sgRNA to produce transgenic Duncan grapefruit alleviating XccΔpthA4:dCsLOB1.3 infection&author=Jia H.&author=Orbovic V.&author=Jones J.B.&author=Wang N.&publication_year=2016&journal=Plant Biotechnol J&volume=14&pages=1291-1301

[49] Jiang W., Zhou H., Bi H., Fromm M., Yang B., Weeks D.P.. Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res, 2013, 41: e188 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice&author=Jiang W.&author=Zhou H.&author=Bi H.&author=Fromm M.&author=Yang B.&author=Weeks D.P.&publication_year=2013&journal=Nucleic Acids Res&volume=41&pages=e188

[50] Jiang W.Z., Yang B., Weeks D.P.. Efficient CRISPR/Cas9-mediated gene editing in Arabidopsis thaliana and inheritance of modified genes in the T2 and T3 generations. PLoS ONE, 2014, 9: e99225 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient CRISPR/Cas9-mediated gene editing in Arabidopsis thaliana and inheritance of modified genes in the T2 and T3 generations&author=Jiang W.Z.&author=Yang B.&author=Weeks D.P.&publication_year=2014&journal=PLoS ONE&volume=9&pages=e99225

[51] Jung J.H., Altpeter F.. TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall composition for production of bioethanol. Plant Mol Biol, 2016, 92: 131-142 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall composition for production of bioethanol&author=Jung J.H.&author=Altpeter F.&publication_year=2016&journal=Plant Mol Biol&volume=92&pages=131-142

[52] Kapila J., De Rycke R., Van Montagu M., Angenon G.. An Agrobacterium-mediated transient gene expression system for intact leaves. Plant Sci, 1997, 122: 101-108 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=An Agrobacterium-mediated transient gene expression system for intact leaves&author=Kapila J.&author=De Rycke R.&author=Van Montagu M.&author=Angenon G.&publication_year=1997&journal=Plant Sci&volume=122&pages=101-108

[53] Kelley M.L., Strezoska , He K., Vermeulen A., Smith A.B.. Versatility of chemically synthesized guide RNAs for CRISPR-Cas9 genome editing. J Biotech, 2016, 233: 74-83 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Versatility of chemically synthesized guide RNAs for CRISPR-Cas9 genome editing&author=Kelley M.L.&author=Strezoska &author=He K.&author=Vermeulen A.&author=Smith A.B.&publication_year=2016&journal=J Biotech&volume=233&pages=74-83

[54] Kumagai M.H., Donson J., della-Cioppa G., Harvey D., Hanley K., Grill L.K.. Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA. Proc Natl Acad Sci USA, 1995, 92: 1679-1683 CrossRef ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA&author=Kumagai M.H.&author=Donson J.&author=della-Cioppa G.&author=Harvey D.&author=Hanley K.&author=Grill L.K.&publication_year=1995&journal=Proc Natl Acad Sci USA&volume=92&pages=1679-1683

[55] Lawrenson T., Shorinola O., Stacey N., Li C., ?stergaard L., Patron N., Uauy C., Harwood W.. Induction of targeted, heritable mutations in barley and Brassica oleracea using RNA-guided Cas9 nuclease. Genome Biol, 2015, 16: 258 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Induction of targeted, heritable mutations in barley and Brassica oleracea using RNA-guided Cas9 nuclease&author=Lawrenson T.&author=Shorinola O.&author=Stacey N.&author=Li C.&author=?stergaard L.&author=Patron N.&author=Uauy C.&author=Harwood W.&publication_year=2015&journal=Genome Biol&volume=16&pages=258

[56] Li J.F., Norville J.E., Aach J., McCormack M., Zhang D., Bush J., Church G.M., Sheen J.. Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol, 2013, 31: 688-691 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9&author=Li J.F.&author=Norville J.E.&author=Aach J.&author=McCormack M.&author=Zhang D.&author=Bush J.&author=Church G.M.&author=Sheen J.&publication_year=2013&journal=Nat Biotechnol&volume=31&pages=688-691

[57] Li J., Stoddard T.J., Demorest Z.L., Lavoie P.O., Luo S., Clasen B.M., Cedrone F., Ray E.E., Coffman A.P., Daulhac A., Yabandith A., Retterath A.J., Mathis L., Voytas D.F., D’Aoust M.A., Zhang F.. Multiplexed, targeted gene editing in Nicotiana benthamiana for glyco-engineering and monoclonal antibody production. Plant Biotechnol J, 2016, 14: 533-542 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Multiplexed, targeted gene editing in Nicotiana benthamiana for glyco-engineering and monoclonal antibody production&author=Li J.&author=Stoddard T.J.&author=Demorest Z.L.&author=Lavoie P.O.&author=Luo S.&author=Clasen B.M.&author=Cedrone F.&author=Ray E.E.&author=Coffman A.P.&author=Daulhac A.&author=Yabandith A.&author=Retterath A.J.&author=Mathis L.&author=Voytas D.F.&author=D’Aoust M.A.&author=Zhang F.&publication_year=2016&journal=Plant Biotechnol J&volume=14&pages=533-542

[58] Li T., Liu B., Spalding M.H., Weeks D.P., Yang B.. High-efficiency TALEN-based gene editing produces disease-resistant rice. Nat Biotechnol, 2012, 30: 390-392 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=High-efficiency TALEN-based gene editing produces disease-resistant rice&author=Li T.&author=Liu B.&author=Spalding M.H.&author=Weeks D.P.&author=Yang B.&publication_year=2012&journal=Nat Biotechnol&volume=30&pages=390-392

[59] Li T., Liu B., Chen C.Y., Yang B.. TALEN-mediated homologous recombination produces site-directed DNA base change and herbicide-resistant rice. J Genet Genomics, 2016, 43: 297-305 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=TALEN-mediated homologous recombination produces site-directed DNA base change and herbicide-resistant rice&author=Li T.&author=Liu B.&author=Chen C.Y.&author=Yang B.&publication_year=2016&journal=J Genet Genomics&volume=43&pages=297-305

[60] Li Z., Liu Z.B., Xing A., Moon B.P., Koellhoffer J.P., Huang L., Ward R.T., Clifton E., Falco S.C., Cigan A.M.. Cas9-guide RNA directed genome editing in soybean. Plant Physiol, 2015, 169: 960-970 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Cas9-guide RNA directed genome editing in soybean&author=Li Z.&author=Liu Z.B.&author=Xing A.&author=Moon B.P.&author=Koellhoffer J.P.&author=Huang L.&author=Ward R.T.&author=Clifton E.&author=Falco S.C.&author=Cigan A.M.&publication_year=2015&journal=Plant Physiol&volume=169&pages=960-970

[61] Liang Z., Zhang K., Chen K., Gao C.. Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system. J Genet Genomics, 2014, 41: 63-68 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system&author=Liang Z.&author=Zhang K.&author=Chen K.&author=Gao C.&publication_year=2014&journal=J Genet Genomics&volume=41&pages=63-68

[62] Liang Z., Chen K., Li T., Zhang Y., Wang Y., Zhao Q., Liu J., Zhang H., Liu C., Ran Y., Gao C.. Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes. Nat Commun, 2017, 8: 14261 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes&author=Liang Z.&author=Chen K.&author=Li T.&author=Zhang Y.&author=Wang Y.&author=Zhao Q.&author=Liu J.&author=Zhang H.&author=Liu C.&author=Ran Y.&author=Gao C.&publication_year=2017&journal=Nat Commun&volume=8&pages=14261

[63] Lloyd A., Plaisier C.L., Carroll D., Drews G.N.. Targeted mutagenesis using zinc-finger nucleases in Arabidopsis. Proc Natl Acad Sci USA, 2005, 102: 2232-2237 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis using zinc-finger nucleases in Arabidopsis&author=Lloyd A.&author=Plaisier C.L.&author=Carroll D.&author=Drews G.N.&publication_year=2005&journal=Proc Natl Acad Sci USA&volume=102&pages=2232-2237

[64] Lor V.S., Starker C.G., Voytas D.F., Weiss D., Olszewski N.E.. Targeted mutagenesis of the tomato PROCERA gene using transcription activator-like effector nucleases. Plant Physiol, 2014, 166: 1288-1291 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis of the tomato PROCERA gene using transcription activator-like effector nucleases&author=Lor V.S.&author=Starker C.G.&author=Voytas D.F.&author=Weiss D.&author=Olszewski N.E.&publication_year=2014&journal=Plant Physiol&volume=166&pages=1288-1291

[65] Lowe K., Wu E., Wang N., Hoerster G., Hastings C., Cho M.J., Scelonge C., Lenderts B., Chamberlin M., Cushatt J., Wang L., Ryan L., Khan T., Chow-Yiu J., Hua W., Yu M., Banh J., Bao Z., Brink K., Igo E., Rudrappa B., Shamseer P.M., Bruce W., Newman L., Shen B., Zheng P., Bidney D., Falco S.C., RegisterIII J.C., Zhao Z.Y., Xu D., Jones T.J., Gordon-Kamm W.J.. Morphogenic regulators Baby boom and Wuschel improve monocot transformation. Plant Cell, 2016, 28: 1998-2015 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Morphogenic regulators Baby boom and Wuschel improve monocot transformation&author=Lowe K.&author=Wu E.&author=Wang N.&author=Hoerster G.&author=Hastings C.&author=Cho M.J.&author=Scelonge C.&author=Lenderts B.&author=Chamberlin M.&author=Cushatt J.&author=Wang L.&author=Ryan L.&author=Khan T.&author=Chow-Yiu J.&author=Hua W.&author=Yu M.&author=Banh J.&author=Bao Z.&author=Brink K.&author=Igo E.&author=Rudrappa B.&author=Shamseer P.M.&author=Bruce W.&author=Newman L.&author=Shen B.&author=Zheng P.&author=Bidney D.&author=Falco S.C.&author=RegisterIII J.C.&author=Zhao Z.Y.&author=Xu D.&author=Jones T.J.&author=Gordon-Kamm W.J.&publication_year=2016&journal=Plant Cell&volume=28&pages=1998-2015

[66] Luo S., Li J., Stoddard T.J., Baltes N.J., Demorest Z.L., Clasen B.M., Coffman A., Retterath A., Mathis L., Voytas D.F., Zhang F.. Non-transgenic plant genome editing using purified sequence-specific nucleases. Mol Plant, 2015, 8: 1425-1427 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Non-transgenic plant genome editing using purified sequence-specific nucleases&author=Luo S.&author=Li J.&author=Stoddard T.J.&author=Baltes N.J.&author=Demorest Z.L.&author=Clasen B.M.&author=Coffman A.&author=Retterath A.&author=Mathis L.&author=Voytas D.F.&author=Zhang F.&publication_year=2015&journal=Mol Plant&volume=8&pages=1425-1427

[67] Ma X., Zhang Q., Zhu Q., Liu W., Chen Y., Qiu R., Wang B., Yang Z., Li H., Lin Y., Xie Y., Shen R., Chen S., Wang Z., Chen Y., Guo J., Chen L., Zhao X., Dong Z., Liu Y.G.. A robust CRISPR/Cas9 system for convenient, high-efficiency multiplex genome editing in monocot and dicotplants. Mol Plant, 2015, 8: 1274-1284 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=A robust CRISPR/Cas9 system for convenient, high-efficiency multiplex genome editing in monocot and dicotplants&author=Ma X.&author=Zhang Q.&author=Zhu Q.&author=Liu W.&author=Chen Y.&author=Qiu R.&author=Wang B.&author=Yang Z.&author=Li H.&author=Lin Y.&author=Xie Y.&author=Shen R.&author=Chen S.&author=Wang Z.&author=Chen Y.&author=Guo J.&author=Chen L.&author=Zhao X.&author=Dong Z.&author=Liu Y.G.&publication_year=2015&journal=Mol Plant&volume=8&pages=1274-1284

[68] Mahfouz M.M., Li L., Shamimuzzaman M., Wibowo A., Fang X., Zhu J.K.. De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci USA, 2011, 108: 2623-2628 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks&author=Mahfouz M.M.&author=Li L.&author=Shamimuzzaman M.&author=Wibowo A.&author=Fang X.&author=Zhu J.K.&publication_year=2011&journal=Proc Natl Acad Sci USA&volume=108&pages=2623-2628

[69] Malnoy M., Viola R., Jung M.H., Koo O.J., Kim S., Kim J.S., Velasco R., Nagamangala Kanchiswamy C.. DNA-free genetically edited grapevine and apple protoplast using CRISPR/Cas9 ribonucleoproteins. Front Plant Sci, 2016, 7: 1904 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=DNA-free genetically edited grapevine and apple protoplast using CRISPR/Cas9 ribonucleoproteins&author=Malnoy M.&author=Viola R.&author=Jung M.H.&author=Koo O.J.&author=Kim S.&author=Kim J.S.&author=Velasco R.&author=Nagamangala Kanchiswamy C.&publication_year=2016&journal=Front Plant Sci&volume=7&pages=1904

[70] Mao Y., Zhang H., Xu N., Zhang B., Gou F., Zhu J.K.. Application of the CRISPR-Cas system for efficient genome engineering in plants. Mol Plant, 2013, 6: 2008-2011 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Application of the CRISPR-Cas system for efficient genome engineering in plants&author=Mao Y.&author=Zhang H.&author=Xu N.&author=Zhang B.&author=Gou F.&author=Zhu J.K.&publication_year=2013&journal=Mol Plant&volume=6&pages=2008-2011

[71] Martin-Ortigosa S., Valenstein J.S., Lin V.S.Y., Trewyn B.G., Wang K.. Gold functionalized mesoporous silica nanoparticle mediated protein and DNA codelivery to plant cells via the biolistic method. Adv Funct Mater, 2012, 22: 3576-3582 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Gold functionalized mesoporous silica nanoparticle mediated protein and DNA codelivery to plant cells via the biolistic method&author=Martin-Ortigosa S.&author=Valenstein J.S.&author=Lin V.S.Y.&author=Trewyn B.G.&author=Wang K.&publication_year=2012&journal=Adv Funct Mater&volume=22&pages=3576-3582

[72] Martin-Ortigosa S., Peterson D.J., Valenstein J.S., Lin V.S.Y., Trewyn B.G., Lyznik L.A., Wang K.. Mesoporous silica nanoparticle-mediated intracellular Cre protein delivery for maize genome editing via loxP site excision. Plant Physiol, 2014, 164: 537-547 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Mesoporous silica nanoparticle-mediated intracellular Cre protein delivery for maize genome editing via loxP site excision&author=Martin-Ortigosa S.&author=Peterson D.J.&author=Valenstein J.S.&author=Lin V.S.Y.&author=Trewyn B.G.&author=Lyznik L.A.&author=Wang K.&publication_year=2014&journal=Plant Physiol&volume=164&pages=537-547

[73] Marton I., Zuker A., Shklarman E., Zeevi V., Tovkach A., Roffe S., Ovadis M., Tzfira T., Vainstein A.. Nontransgenic genome modification in plant cells. Plant Physiol, 2010, 154: 1079-1087 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Nontransgenic genome modification in plant cells&author=Marton I.&author=Zuker A.&author=Shklarman E.&author=Zeevi V.&author=Tovkach A.&author=Roffe S.&author=Ovadis M.&author=Tzfira T.&author=Vainstein A.&publication_year=2010&journal=Plant Physiol&volume=154&pages=1079-1087

[74] Miao J., Guo D., Zhang J., Huang Q., Qin G., Zhang X., Wan J., Gu H., Qu L.J.. Targeted mutagenesis in rice using CRISPR-Cas system. Cell Res, 2013, 23: 1233-1236 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis in rice using CRISPR-Cas system&author=Miao J.&author=Guo D.&author=Zhang J.&author=Huang Q.&author=Qin G.&author=Zhang X.&author=Wan J.&author=Gu H.&author=Qu L.J.&publication_year=2013&journal=Cell Res&volume=23&pages=1233-1236

[75] Mikami M., Toki S., Endo M.. Comparison of CRISPR/Cas9 expression constructs for efficient targeted mutagenesis in rice. Plant Mol Biol, 2015, 88: 561-572 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Comparison of CRISPR/Cas9 expression constructs for efficient targeted mutagenesis in rice&author=Mikami M.&author=Toki S.&author=Endo M.&publication_year=2015&journal=Plant Mol Biol&volume=88&pages=561-572

[76] Mikami M., Toki S., Endo M.. Precision targeted mutagenesis via Cas9 paired nickases in rice. Plant Cell Physiol, 2016, 57: 1058-1068 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Precision targeted mutagenesis via Cas9 paired nickases in rice&author=Mikami M.&author=Toki S.&author=Endo M.&publication_year=2016&journal=Plant Cell Physiol&volume=57&pages=1058-1068

[77] Nekrasov V., Staskawicz B., Weigel D., Jones J.D.G., Kamoun S.. Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease. Nat Biotechnol, 2013, 31: 691-693 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease&author=Nekrasov V.&author=Staskawicz B.&author=Weigel D.&author=Jones J.D.G.&author=Kamoun S.&publication_year=2013&journal=Nat Biotechnol&volume=31&pages=691-693

[78] Nicolia A., Proux-Wéra E., ?hman I., Onkokesung N., Andersson M., Andreasson E., Zhu L.H.. Targeted gene mutation in tetraploid potato through transient TALEN expression in protoplasts. J Biotech, 2015, 204: 17-24 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted gene mutation in tetraploid potato through transient TALEN expression in protoplasts&author=Nicolia A.&author=Proux-Wéra E.&author=?hman I.&author=Onkokesung N.&author=Andersson M.&author=Andreasson E.&author=Zhu L.H.&publication_year=2015&journal=J Biotech&volume=204&pages=17-24

[79] Okuzaki A., Toriyama K.. Chimeric RNA/DNA oligonucleotide-directed gene targeting in rice. Plant Cell Rep, 2004, 22: 509-512 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Chimeric RNA/DNA oligonucleotide-directed gene targeting in rice&author=Okuzaki A.&author=Toriyama K.&publication_year=2004&journal=Plant Cell Rep&volume=22&pages=509-512

[80] Osakabe K., Osakabe Y., Toki S.. Site-directed mutagenesis in Arabidopsis using custom-designed zinc finger nucleases. Proc Natl Acad Sci USA, 2010, 107: 12034-12039 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Site-directed mutagenesis in Arabidopsis using custom-designed zinc finger nucleases&author=Osakabe K.&author=Osakabe Y.&author=Toki S.&publication_year=2010&journal=Proc Natl Acad Sci USA&volume=107&pages=12034-12039

[81] Paul J.W., Qi Y.. CRISPR/Cas9 for plant genome editing: accomplishments, problems and prospects. Plant Cell Rep, 2016, 35: 1417-1427 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=CRISPR/Cas9 for plant genome editing: accomplishments, problems and prospects&author=Paul J.W.&author=Qi Y.&publication_year=2016&journal=Plant Cell Rep&volume=35&pages=1417-1427

[82] Peer R., Rivlin G., Golobovitch S., Lapidot M., Gal-On A., Vainstein A., Tzfira T., Flaishman M.A.. Targeted mutagenesis using zinc-finger nucleases in perennial fruit trees. Planta, 2015, 241: 941-951 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis using zinc-finger nucleases in perennial fruit trees&author=Peer R.&author=Rivlin G.&author=Golobovitch S.&author=Lapidot M.&author=Gal-On A.&author=Vainstein A.&author=Tzfira T.&author=Flaishman M.A.&publication_year=2015&journal=Planta&volume=241&pages=941-951

[83] Petolino J.F.. Genome editing in plants via designed zinc finger nucleases. Cell Dev Biol-Plant, 2015, 51: 1-8 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Genome editing in plants via designed zinc finger nucleases&author=Petolino J.F.&publication_year=2015&journal=Cell Dev Biol-Plant&volume=51&pages=1-8

[84] Piatek A., Ali Z., Baazim H., Li L., Abulfaraj A., Al-Shareef S., Aouida M., Mahfouz M.M.. RNA-guided transcriptional regulation in planta via synthetic dCas9-based transcription factors. Plant Biotechnol J, 2015, 13: 578-589 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=RNA-guided transcriptional regulation in planta via synthetic dCas9-based transcription factors&author=Piatek A.&author=Ali Z.&author=Baazim H.&author=Li L.&author=Abulfaraj A.&author=Al-Shareef S.&author=Aouida M.&author=Mahfouz M.M.&publication_year=2015&journal=Plant Biotechnol J&volume=13&pages=578-589

[85] Popat A., Hartono S.B., Stahr F., Liu J., Qiao S.Z., Qing (Max) Lu G.. Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers. Nanoscale, 2011, 3: 2801-2818 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers&author=Popat A.&author=Hartono S.B.&author=Stahr F.&author=Liu J.&author=Qiao S.Z.&author=Qing (Max) Lu G.&publication_year=2011&journal=Nanoscale&volume=3&pages=2801-2818

[86] Pratt, S. Growers to see new HT canola in 2016. The Western Producer. 2012-05-28. http://www.producer.com/2014/03/growers-to-see-new-ht-canola-in-2016/. Google Scholar http://scholar.google.com/scholar_lookup?title=Pratt, S. Growers to see new HT canola in 2016. The Western Producer. 2012-05-28. http://www.producer.com/2014/03/growers-to-see-new-ht-canola-in-2016/&

[87] Qi Y., Zhang Y., Zhang F., Baller J.A., Cleland S.C., Ryu Y., Starker C.G., Voytas D.F.. Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways. Genome Res, 2013a, 23: 547-554 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways&author=Qi Y.&author=Zhang Y.&author=Zhang F.&author=Baller J.A.&author=Cleland S.C.&author=Ryu Y.&author=Starker C.G.&author=Voytas D.F.&publication_year=2013a&journal=Genome Res&volume=23&pages=547-554

[88] Qi Y., Li X., Zhang Y., Starker C.G., Baltes N.J., Zhang F., Sander J.D., Reyon D., Joung J.K., Voytas D.F.. Targeted deletion and inversion of tandemly arrayed genes in Arabidopsis thaliana using zinc finger nucleases. G3, 2013b, 3: 1707-1715 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted deletion and inversion of tandemly arrayed genes in Arabidopsis thaliana using zinc finger nucleases&author=Qi Y.&author=Li X.&author=Zhang Y.&author=Starker C.G.&author=Baltes N.J.&author=Zhang F.&author=Sander J.D.&author=Reyon D.&author=Joung J.K.&author=Voytas D.F.&publication_year=2013b&journal=G3&volume=3&pages=1707-1715

[89] Raitskin O., Patron N.J.. Multi-gene engineering in plants with RNA-guided Cas9 nuclease. Curr Opin Biotech, 2016, 37: 69-75 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Multi-gene engineering in plants with RNA-guided Cas9 nuclease&author=Raitskin O.&author=Patron N.J.&publication_year=2016&journal=Curr Opin Biotech&volume=37&pages=69-75

[90] Rakoczy-Trojanowska, M. (2002). Alternative methods of plant transformation: a short review. Cell Mol Biol Lett 7, 849–858. Google Scholar http://scholar.google.com/scholar_lookup?title=Rakoczy-Trojanowska, M. (2002). Alternative methods of plant transformation: a short review. Cell Mol Biol Lett 7, 849–858&

[91] Ren C., Liu X., Zhang Z., Wang Y., Duan W., Li S., Liang Z.. CRISPR/Cas9-mediated efficient targeted mutagenesis in Chardonnay (Vitis vinifera L.). Sci Rep, 2016, 6: 32289 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=CRISPR/Cas9-mediated efficient targeted mutagenesis in Chardonnay (Vitis vinifera L.)&author=Ren C.&author=Liu X.&author=Zhang Z.&author=Wang Y.&author=Duan W.&author=Li S.&author=Liang Z.&publication_year=2016&journal=Sci Rep&volume=6&pages=32289

[92] Rinaldo A.R., Ayliffe M.. Gene targeting and editing in crop plants: a new era of precision opportunities. Mol Breeding, 2015, 35: 40 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Gene targeting and editing in crop plants: a new era of precision opportunities&author=Rinaldo A.R.&author=Ayliffe M.&publication_year=2015&journal=Mol Breeding&volume=35&pages=40

[93] Sauer N.J., Narváez-Vásquez J., Mozoruk J., Miller R.B., Warburg Z.J., Woodward M.J., Mihiret Y.A., Lincoln T.A., Segami R.E., Sanders S.L., Walker K.A., Beetham P.R., Sch?pke C.R., Gocal G.F.W.. Oligonucleotide-mediated genome editing provides precision and function to engineered nucleases and antibiotics in plants. Plant Physiol, 2016, 170: 1917-1928 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Oligonucleotide-mediated genome editing provides precision and function to engineered nucleases and antibiotics in plants&author=Sauer N.J.&author=Narváez-Vásquez J.&author=Mozoruk J.&author=Miller R.B.&author=Warburg Z.J.&author=Woodward M.J.&author=Mihiret Y.A.&author=Lincoln T.A.&author=Segami R.E.&author=Sanders S.L.&author=Walker K.A.&author=Beetham P.R.&author=Sch?pke C.R.&author=Gocal G.F.W.&publication_year=2016&journal=Plant Physiol&volume=170&pages=1917-1928

[94] Schaeffer S.M., Nakata P.A.. CRISPR/Cas9-mediated genome editing and gene replacement in plants: transitioning from lab to field. Plant Sci, 2015, 240: 130-142 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=CRISPR/Cas9-mediated genome editing and gene replacement in plants: transitioning from lab to field&author=Schaeffer S.M.&author=Nakata P.A.&publication_year=2015&journal=Plant Sci&volume=240&pages=130-142

[95] Schiml S., Fauser F., Puchta H.. The CRISPR/Cas system can be used as nuclease for in planta gene targeting and as paired nickases for directed mutagenesis in Arabidopsis resulting in heritable progeny. Plant J, 2014, 80: 1139-1150 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=The CRISPR/Cas system can be used as nuclease for in planta gene targeting and as paired nickases for directed mutagenesis in Arabidopsis resulting in heritable progeny&author=Schiml S.&author=Fauser F.&author=Puchta H.&publication_year=2014&journal=Plant J&volume=80&pages=1139-1150

[96] Shan Q., Wang Y., Chen K., Liang Z., Li J., Zhang Y., Zhang K., Liu J., Voytas D.F., Zheng X., Zhang Y., Gao C.. Rapid and efficient gene modification in rice and Brachypodium using TALENs. Mol Plant, 2013a, 6: 1365-1368 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Rapid and efficient gene modification in rice and Brachypodium using TALENs&author=Shan Q.&author=Wang Y.&author=Chen K.&author=Liang Z.&author=Li J.&author=Zhang Y.&author=Zhang K.&author=Liu J.&author=Voytas D.F.&author=Zheng X.&author=Zhang Y.&author=Gao C.&publication_year=2013a&journal=Mol Plant&volume=6&pages=1365-1368

[97] Shan Q., Wang Y., Li J., Zhang Y., Chen K., Liang Z., Zhang K., Liu J., Xi J.J., Qiu J.L., Gao C.. Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol, 2013b, 31: 686-688 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted genome modification of crop plants using a CRISPR-Cas system&author=Shan Q.&author=Wang Y.&author=Li J.&author=Zhang Y.&author=Chen K.&author=Liang Z.&author=Zhang K.&author=Liu J.&author=Xi J.J.&author=Qiu J.L.&author=Gao C.&publication_year=2013b&journal=Nat Biotechnol&volume=31&pages=686-688

[98] Shan Q., Zhang Y., Chen K., Zhang K., Gao C.. Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology. Plant Biotechnol J, 2015, 13: 791-800 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology&author=Shan Q.&author=Zhang Y.&author=Chen K.&author=Zhang K.&author=Gao C.&publication_year=2015&journal=Plant Biotechnol J&volume=13&pages=791-800

[99] Shi J., Gao H., Wang H., Lafitte H.R., Archibald R.L., Yang M., Hakimi S.M., Mo H., Habben J.E.. ARGOS8 variants generated by CRISPR-Cas9 improve maize grain yield under field drought stress conditions. Plant Biotechnol J, 2017, 15: 207-216 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=ARGOS8 variants generated by CRISPR-Cas9 improve maize grain yield under field drought stress conditions&author=Shi J.&author=Gao H.&author=Wang H.&author=Lafitte H.R.&author=Archibald R.L.&author=Yang M.&author=Hakimi S.M.&author=Mo H.&author=Habben J.E.&publication_year=2017&journal=Plant Biotechnol J&volume=15&pages=207-216

[100] Shukla V.K., Doyon Y., Miller J.C., DeKelver R.C., Moehle E.A., Worden S.E., Mitchell J.C., Arnold N.L., Gopalan S., Meng X., Choi V.M., Rock J.M., Wu Y.Y., Katibah G.E., Zhifang G., McCaskill D., Simpson M.A., Blakeslee B., Greenwalt S.A., Butler H.J., Hinkley S.J., Zhang L., Rebar E.J., Gregory P.D., Urnov F.D.. Precise genome modification in the crop species Zea mays using zinc-finger nucleases. Nature, 2009, 459: 437-441 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Precise genome modification in the crop species Zea mays using zinc-finger nucleases&author=Shukla V.K.&author=Doyon Y.&author=Miller J.C.&author=DeKelver R.C.&author=Moehle E.A.&author=Worden S.E.&author=Mitchell J.C.&author=Arnold N.L.&author=Gopalan S.&author=Meng X.&author=Choi V.M.&author=Rock J.M.&author=Wu Y.Y.&author=Katibah G.E.&author=Zhifang G.&author=McCaskill D.&author=Simpson M.A.&author=Blakeslee B.&author=Greenwalt S.A.&author=Butler H.J.&author=Hinkley S.J.&author=Zhang L.&author=Rebar E.J.&author=Gregory P.D.&author=Urnov F.D.&publication_year=2009&journal=Nature&volume=459&pages=437-441

[101] Stoddard T.J., Clasen B.M., Baltes N.J., Demorest Z.L., Voytas D.F., Zhang F., Luo S.. Targeted mutagenesis in plant cells through transformation of sequence-specific nuclease mRNA. PLoS ONE, 2016, 11: e0154634 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis in plant cells through transformation of sequence-specific nuclease mRNA&author=Stoddard T.J.&author=Clasen B.M.&author=Baltes N.J.&author=Demorest Z.L.&author=Voytas D.F.&author=Zhang F.&author=Luo S.&publication_year=2016&journal=PLoS ONE&volume=11&pages=e0154634

[102] Sugano S.S., Shirakawa M., Takagi J., Matsuda Y., Shimada T., Hara-Nishimura I., Kohchi T.. CRISPR/Cas9-mediated targeted mutagenesis in the liverwort Marchantia polymorpha L.. Plant Cell Physiol, 2014, 55: 475-481 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=CRISPR/Cas9-mediated targeted mutagenesis in the liverwort Marchantia polymorpha L.&author=Sugano S.S.&author=Shirakawa M.&author=Takagi J.&author=Matsuda Y.&author=Shimada T.&author=Hara-Nishimura I.&author=Kohchi T.&publication_year=2014&journal=Plant Cell Physiol&volume=55&pages=475-481

[103] Sun X., Hu Z., Chen R., Jiang Q., Song G., Zhang H., Xi Y.. Targeted mutagenesis in soybean using the CRISPR-Cas9 system. Sci Rep, 2015, 5: 10342 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis in soybean using the CRISPR-Cas9 system&author=Sun X.&author=Hu Z.&author=Chen R.&author=Jiang Q.&author=Song G.&author=Zhang H.&author=Xi Y.&publication_year=2015&journal=Sci Rep&volume=5&pages=10342

[104] Svitashev S., Young J.K., Schwartz C., Gao H., Falco S.C., Cigan A.M.. Targeted mutagenesis, precise gene editing, and site-specific gene insertion in maize using Cas9 and guide RNA. Plant Physiol, 2015, 169: 931-945 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted mutagenesis, precise gene editing, and site-specific gene insertion in maize using Cas9 and guide RNA&author=Svitashev S.&author=Young J.K.&author=Schwartz C.&author=Gao H.&author=Falco S.C.&author=Cigan A.M.&publication_year=2015&journal=Plant Physiol&volume=169&pages=931-945

[105] Svitashev S., Schwartz C., Lenderts B., Young J.K., Mark Cigan A.. Genome editing in maize directed by CRISPR-Cas9 ribonucleoprotein complexes. Nat Commun, 2016, 7: 13274 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Genome editing in maize directed by CRISPR-Cas9 ribonucleoprotein complexes&author=Svitashev S.&author=Schwartz C.&author=Lenderts B.&author=Young J.K.&author=Mark Cigan A.&publication_year=2016&journal=Nat Commun&volume=7&pages=13274

[106] Torney F., Trewyn B.G., Lin V.S.Y., Wang K.. Mesoporous silica nanoparticles deliver DNA and chemicals into plants. Nat Nanotech, 2007, 2: 295-300 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Mesoporous silica nanoparticles deliver DNA and chemicals into plants&author=Torney F.&author=Trewyn B.G.&author=Lin V.S.Y.&author=Wang K.&publication_year=2007&journal=Nat Nanotech&volume=2&pages=295-300

[107] Tovkach A., Zeevi V., Tzfira T.. A toolbox and procedural notes for characterizing novel zinc finger nucleases for genome editing in plant cells. Plant J, 2009, 57: 747-757 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=A toolbox and procedural notes for characterizing novel zinc finger nucleases for genome editing in plant cells&author=Tovkach A.&author=Zeevi V.&author=Tzfira T.&publication_year=2009&journal=Plant J&volume=57&pages=747-757

[108] Townsend J.A., Wright D.A., Winfrey R.J., Fu F., Maeder M.L., Joung J.K., Voytas D.F.. High-frequency modification of plant genes using engineered zinc-finger nucleases. Nature, 2009, 459: 442-445 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=High-frequency modification of plant genes using engineered zinc-finger nucleases&author=Townsend J.A.&author=Wright D.A.&author=Winfrey R.J.&author=Fu F.&author=Maeder M.L.&author=Joung J.K.&author=Voytas D.F.&publication_year=2009&journal=Nature&volume=459&pages=442-445

[109] Upadhyay S.K., Kumar J., Alok A., Tuli R.. RNA-guided genome editing for target gene mutations in wheat. G3, 2013, 3: 2233-2238 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=RNA-guided genome editing for target gene mutations in wheat&author=Upadhyay S.K.&author=Kumar J.&author=Alok A.&author=Tuli R.&publication_year=2013&journal=G3&volume=3&pages=2233-2238

[110] Vainstein A., Marton I., Zuker A., Danziger M., Tzfira T.. Permanent genome modifications in plant cells by transient viral vectors. Trends Biotech, 2011, 29: 363-369 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Permanent genome modifications in plant cells by transient viral vectors&author=Vainstein A.&author=Marton I.&author=Zuker A.&author=Danziger M.&author=Tzfira T.&publication_year=2011&journal=Trends Biotech&volume=29&pages=363-369

[111] Voytas D.F., Gao C.. Precision genome engineering and agriculture: opportunities and regulatory challenges. PLoS Biol, 2014, 12: e1001877 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Precision genome engineering and agriculture: opportunities and regulatory challenges&author=Voytas D.F.&author=Gao C.&publication_year=2014&journal=PLoS Biol&volume=12&pages=e1001877

[112] Wang S., Zhang S., Wang W., Xiong X., Meng F., Cui X.. Efficient targeted mutagenesis in potato by the CRISPR/Cas9 system. Plant Cell Rep, 2015, 34: 1473-1476 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient targeted mutagenesis in potato by the CRISPR/Cas9 system&author=Wang S.&author=Zhang S.&author=Wang W.&author=Xiong X.&author=Meng F.&author=Cui X.&publication_year=2015&journal=Plant Cell Rep&volume=34&pages=1473-1476

[113] Wang L., Li F., Dang L., Liang C., Wang C., He B., Liu J., Li D., Wu X., Xu X., Lu A., Zhang G.. In vivo delivery systems for therapeutic genome editing. Int J Mol Sci, 2016, 17: 626 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=In vivo delivery systems for therapeutic genome editing&author=Wang L.&author=Li F.&author=Dang L.&author=Liang C.&author=Wang C.&author=He B.&author=Liu J.&author=Li D.&author=Wu X.&author=Xu X.&author=Lu A.&author=Zhang G.&publication_year=2016&journal=Int J Mol Sci&volume=17&pages=626

[114] Wang M., Liu Y., Zhang C., Liu J., Liu X., Wang L., Wang W., Chen H., Wei C., Ye X., Li X., Tu J.. Gene editing by co-transformation of TALEN and chimeric RNA/DNA oligonucleotides on the rice OsEPSPS gene and the inheritance of mutations. PLoS ONE, 2015, 10: e0122755 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Gene editing by co-transformation of TALEN and chimeric RNA/DNA oligonucleotides on the rice OsEPSPS gene and the inheritance of mutations&author=Wang M.&author=Liu Y.&author=Zhang C.&author=Liu J.&author=Liu X.&author=Wang L.&author=Wang W.&author=Chen H.&author=Wei C.&author=Ye X.&author=Li X.&author=Tu J.&publication_year=2015&journal=PLoS ONE&volume=10&pages=e0122755

[115] Wang Y., Cheng X., Shan Q., Zhang Y., Liu J., Gao C., Qiu J.L.. Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nat Biotechnol, 2014, 32: 947-951 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew&author=Wang Y.&author=Cheng X.&author=Shan Q.&author=Zhang Y.&author=Liu J.&author=Gao C.&author=Qiu J.L.&publication_year=2014&journal=Nat Biotechnol&volume=32&pages=947-951

[116] Wang Z.P., Xing H.L., Dong L., Zhang H.Y., Han C.Y., Wang X.C., Chen Q.J.. Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation. Genome Biol, 2015, 16: 144 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation&author=Wang Z.P.&author=Xing H.L.&author=Dong L.&author=Zhang H.Y.&author=Han C.Y.&author=Wang X.C.&author=Chen Q.J.&publication_year=2015&journal=Genome Biol&volume=16&pages=144

[117] Weeks D.P., Spalding M.H., Yang B.. Use of designer nucleases for targeted gene and genome editing in plants. Plant Biotechnol J, 2016, 14: 483-495 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Use of designer nucleases for targeted gene and genome editing in plants&author=Weeks D.P.&author=Spalding M.H.&author=Yang B.&publication_year=2016&journal=Plant Biotechnol J&volume=14&pages=483-495

[118] Wendt T., Holm P.B., Starker C.G., Christian M., Voytas D.F., Brinch-Pedersen H., Holme I.B.. TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants. Plant Mol Biol, 2013, 83: 279-285 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants&author=Wendt T.&author=Holm P.B.&author=Starker C.G.&author=Christian M.&author=Voytas D.F.&author=Brinch-Pedersen H.&author=Holme I.B.&publication_year=2013&journal=Plant Mol Biol&volume=83&pages=279-285

[119] Weinthal D., Tovkach A., Zeevi V., Tzfira T.. Genome editing in plant cells by zinc finger nucleases. Trends Plant Sci, 2010, 15: 308-321 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Genome editing in plant cells by zinc finger nucleases&author=Weinthal D.&author=Tovkach A.&author=Zeevi V.&author=Tzfira T.&publication_year=2010&journal=Trends Plant Sci&volume=15&pages=308-321

[120] Woo J.W., Kim J., Kwon S.I., Corvalán C., Cho S.W., Kim H., Kim S.G., Kim S.T., Choe S., Kim J.S.. DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins. Nat Biotechnol, 2015, 33: 1162-1164 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins&author=Woo J.W.&author=Kim J.&author=Kwon S.I.&author=Corvalán C.&author=Cho S.W.&author=Kim H.&author=Kim S.G.&author=Kim S.T.&author=Choe S.&author=Kim J.S.&publication_year=2015&journal=Nat Biotechnol&volume=33&pages=1162-1164

[121] Wright D.A., Townsend J.A., Winfrey Jr R.J., Irwin P.A., Rajagopal J., Lonosky P.M., Hall B.D., Jondle M.D., Voytas D.F.. High-frequency homologous recombination in plants mediated by zinc-finger nucleases. Plant J, 2005, 44: 693-705 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=High-frequency homologous recombination in plants mediated by zinc-finger nucleases&author=Wright D.A.&author=Townsend J.A.&author=Winfrey Jr R.J.&author=Irwin P.A.&author=Rajagopal J.&author=Lonosky P.M.&author=Hall B.D.&author=Jondle M.D.&author=Voytas D.F.&publication_year=2005&journal=Plant J&volume=44&pages=693-705

[122] Xie K., Yang Y.. RNA-guided genome editing in plants using a CRISPR-Cas system. Mol Plant, 2013, 6: 1975-1983 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=RNA-guided genome editing in plants using a CRISPR-Cas system&author=Xie K.&author=Yang Y.&publication_year=2013&journal=Mol Plant&volume=6&pages=1975-1983

[123] Xie K., Minkenberg B., Yang Y.. Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system. Proc Natl Acad Sci USA, 2015, 112: 3570-3575 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system&author=Xie K.&author=Minkenberg B.&author=Yang Y.&publication_year=2015&journal=Proc Natl Acad Sci USA&volume=112&pages=3570-3575

[124] Xing H.L., Dong L., Wang Z.P., Zhang H.Y., Han C.Y., Liu B., Wang X.C., Chen Q.J.. A CRISPR/Cas9 toolkit for multiplex genome editing in plants. BMC Plant Biol, 2014, 14: 327 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=A CRISPR/Cas9 toolkit for multiplex genome editing in plants&author=Xing H.L.&author=Dong L.&author=Wang Z.P.&author=Zhang H.Y.&author=Han C.Y.&author=Liu B.&author=Wang X.C.&author=Chen Q.J.&publication_year=2014&journal=BMC Plant Biol&volume=14&pages=327

[125] Xu R., Li H., Qin R., Wang L., Li L., Wei P., Yang J.. Gene targeting using the Agrobacterium tumefaciens-mediated CRISPR-Cas system in rice. Rice, 2014, 7: 5 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Gene targeting using the Agrobacterium tumefaciens-mediated CRISPR-Cas system in rice&author=Xu R.&author=Li H.&author=Qin R.&author=Wang L.&author=Li L.&author=Wei P.&author=Yang J.&publication_year=2014&journal=Rice&volume=7&pages=5

[126] Yan L., Wei S., Wu Y., Hu R., Li H., Yang W., Xie Q.. High-efficiency genome editing in Arabidopsis using YAO promoter-driven CRISPR/Cas9 system. Mol Plant, 2015, 8: 1820-1823 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=High-efficiency genome editing in Arabidopsis using YAO promoter-driven CRISPR/Cas9 system&author=Yan L.&author=Wei S.&author=Wu Y.&author=Hu R.&author=Li H.&author=Yang W.&author=Xie Q.&publication_year=2015&journal=Mol Plant&volume=8&pages=1820-1823

[127] Yin K., Han T., Liu G., Chen T., Wang Y., Yu A.Y.L., Liu Y.. A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing. Sci Rep, 2015, 5: 14926 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing&author=Yin K.&author=Han T.&author=Liu G.&author=Chen T.&author=Wang Y.&author=Yu A.Y.L.&author=Liu Y.&publication_year=2015&journal=Sci Rep&volume=5&pages=14926

[128] Yoon K., Cole-Strauss A., Kmiec E.B.. Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide. Proc Natl Acad Sci USA, 1996, 93: 2071-2076 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide&author=Yoon K.&author=Cole-Strauss A.&author=Kmiec E.B.&publication_year=1996&journal=Proc Natl Acad Sci USA&volume=93&pages=2071-2076

[129] Zhang F., Maeder M.L., Unger-Wallace E., Hoshaw J.P., Reyon D., Christian M., Li X., Pierick C.J., Dobbs D., Peterson T., Joung J.K., Voytas D.F.. High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases. Proc Natl Acad Sci USA, 2010, 107: 12028-12033 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases&author=Zhang F.&author=Maeder M.L.&author=Unger-Wallace E.&author=Hoshaw J.P.&author=Reyon D.&author=Christian M.&author=Li X.&author=Pierick C.J.&author=Dobbs D.&author=Peterson T.&author=Joung J.K.&author=Voytas D.F.&publication_year=2010&journal=Proc Natl Acad Sci USA&volume=107&pages=12028-12033

[130] Zhang H., Zhang J., Wei P., Zhang B., Gou F., Feng Z., Mao Y., Yang L., Zhang H., Xu N., Zhu J.K.. The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation. Plant Biotechnol J, 2014, 12: 797-807 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation&author=Zhang H.&author=Zhang J.&author=Wei P.&author=Zhang B.&author=Gou F.&author=Feng Z.&author=Mao Y.&author=Yang L.&author=Zhang H.&author=Xu N.&author=Zhu J.K.&publication_year=2014&journal=Plant Biotechnol J&volume=12&pages=797-807

[131] Zhang H., Gou F., Zhang J., Liu W., Li Q., Mao Y., Botella J.R., Zhu J.K.. TALEN-mediated targeted mutagenesis produces a large variety of heritable mutations in rice. Plant Biotechnol J, 2016, 14: 186-194 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=TALEN-mediated targeted mutagenesis produces a large variety of heritable mutations in rice&author=Zhang H.&author=Gou F.&author=Zhang J.&author=Liu W.&author=Li Q.&author=Mao Y.&author=Botella J.R.&author=Zhu J.K.&publication_year=2016&journal=Plant Biotechnol J&volume=14&pages=186-194

[132] Zhang Y., Zhang F., Li X., Baller J.A., Qi Y., Starker C.G., Bogdanove A.J., Voytas D.F.. Transcription activator-like effector nucleases enable efficient plant genome engineering. Plant Physiol, 2013, 161: 20-27 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Transcription activator-like effector nucleases enable efficient plant genome engineering&author=Zhang Y.&author=Zhang F.&author=Li X.&author=Baller J.A.&author=Qi Y.&author=Starker C.G.&author=Bogdanove A.J.&author=Voytas D.F.&publication_year=2013&journal=Plant Physiol&volume=161&pages=20-27

[133] Zhang Y., Liang Z., Zong Y., Wang Y., Liu J., Chen K., Qiu J.L., Gao C.. Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA. Nat Commun, 2016, 7: 12617 CrossRef PubMed ADS Google Scholar http://scholar.google.com/scholar_lookup?title=Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA&author=Zhang Y.&author=Liang Z.&author=Zong Y.&author=Wang Y.&author=Liu J.&author=Chen K.&author=Qiu J.L.&author=Gao C.&publication_year=2016&journal=Nat Commun&volume=7&pages=12617

[134] Zhou H., Liu B., Weeks D.P., Spalding M.H., Yang B.. Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice. Nucleic Acids Res, 2014, 42: 10903-10914 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice&author=Zhou H.&author=Liu B.&author=Weeks D.P.&author=Spalding M.H.&author=Yang B.&publication_year=2014&journal=Nucleic Acids Res&volume=42&pages=10903-10914

[135] Zhu T., Peterson D.J., Tagliani L., St. Clair G., Baszczynski C.L., Bowen B.. Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides. Proc Natl Acad Sci USA, 1999, 96: 8768-8773 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides&author=Zhu T.&author=Peterson D.J.&author=Tagliani L.&author=St. Clair G.&author=Baszczynski C.L.&author=Bowen B.&publication_year=1999&journal=Proc Natl Acad Sci USA&volume=96&pages=8768-8773

[136] Zhu T., Mettenburg K., Peterson D.J., Tagliani L., Baszczynski C.L.. Engineering herbicide-resistant maize using chimeric RNA/DNA oligonucleotides. Nat Biotechnol, 2000, 18: 555-558 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Engineering herbicide-resistant maize using chimeric RNA/DNA oligonucleotides&author=Zhu T.&author=Mettenburg K.&author=Peterson D.J.&author=Tagliani L.&author=Baszczynski C.L.&publication_year=2000&journal=Nat Biotechnol&volume=18&pages=555-558